Immature platelet count responses of pediatric patients with immune-mediated thrombotic thrombocytopenic purpura
Hollie M. Reeves a) b), Meng-Lei Zhu c), Robert W. Maitta d) e)
a-Nationwide Children’s Hospital, Department of Pathology and Laboratory Medicine, United States of America
b-Ohio State University College of Medicine, Columbus, OH, United States of America
c-Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, United States of America
d-Department of Pathology, University Hospitals Cleveland Medical Center, United States of America
e-Case Western Reserve University School of Medicine, Cleveland, OH, United States of America
Highlights
• A-IPC on admission of pediatric iTTP patients was depressed below reference range similar to adult patients.
• Low A-IPC on admission predicted ADAMTS13 deficiency testing results.
• A-IPC changes post TPE initiation indicated response to therapy.
• A-IPC instability for cohort predicted presence of inhibitor and characterized therapy response.
• PLT count decreases occurred simultaneously to A-IPC decreases while on therapy.